Functions of neutral ceramidase in the Golgi apparatus

Functions of neutral ceramidase in the Golgi apparatus

Ceramidases hydrolyze ceramides into sphingosine and fatty acids, with sphingosine being further metabolized into sphingosine-1-phosphate (S1P); thus, ceramidases control the levels of these bioactive sphingolipids in cells and tissues. Neutral ceramidase (nCDase) is highly expressed in colorectal t...

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Bibliographic Details
Main Authors: Wataru Sakamoto, Nicolas Coant, Daniel Canals, Lina M. Obeid, Yusuf A. Hannun
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Journal of Lipid Research
Subjects:
neutral ceramidase
sphingolipids
Golgi
apoptosis
colon cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309123

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520309123

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