Design and Synthesis of Analogues of Marine Natural Product Galaxamide, an N-methylated Cyclic Pentapeptide, as Potential Anti-Tumor Agent in Vitro

Design and Synthesis of Analogues of Marine Natural Product Galaxamide, an N-methylated Cyclic Pentapeptide, as Potential Anti-Tumor Agent in Vitro

Herein, we report design and synthesis of novel 26 galaxamide analogues with N-methylated cyclo-pentapeptide, and their in vitro anti-tumor activity towards the panel of human tumor cell line, such as, A549, A549/DPP, HepG2 and SMMC-7721 using MTT assay. We have also investigated the effect of galax...

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Bibliographic Details
Main Authors: Jignesh Lunagariya, Shenghui Zhong, Jianwei Chen, Defa Bai, Poonam Bhadja, Weili Long, Xiaojian Liao, Xiaoli Tang, Shihai Xu
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Marine Drugs
Subjects:
anti-tumor
apoptosis
cyclic pentapeptide
galaxamide analogues
macrocyclisation
Online Access:http://www.mdpi.com/1660-3397/14/9/161

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http://www.mdpi.com/1660-3397/14/9/161

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