Hematologic side effects of immune checkpoint inhibitor with or without chemotherapy in patients with advanced and metastatic gastrointestinal cancer: A systematic review and network meta-analysis of phase 3 trials

Hematologic side effects of immune checkpoint inhibitor with or without chemotherapy in patients with advanced and metastatic gastrointestinal cancer: A systematic review and network meta-analysis of phase 3 trials

Background: The regimens of immune checkpoint inhibitors (ICIs) alone or with chemotherapy are emerging as systemic therapy for patients with advanced and metastatic gastrointestinal cancers. However, the risk of treatment-related hematologic toxicity stays unclear.Methods: We enrolled in phase 3 ra...

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Bibliographic Details
Main Authors: Jingyi Hou, Ruiyang Xie, Zhuo Zhang, Qianxin Liu, Qian Xiang, Yimin Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
hematologic toxicity
immune checkpoint inhibitor
gastrointestinal cancer
phase 3 clinical trial
network meta-analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1163971/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1163971/full

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