Specific DNMT3C flanking sequence preferences facilitate methylation of young murine retrotransposons
Abstract The DNA methyltransferase DNMT3C appeared as a duplication of the DNMT3B gene in muroids and is required for silencing of young retrotransposons in the male germline. Using specialized assay systems, we investigate the flanking sequence preferences of DNMT3C and observe characteristic prefe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06252-z |