Immunobiology of Cellular Transplantation
The goal of cellular transplantation is to allow long-term function of the grafted cells using minimal host immunosuppression. To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immuno...
Main Authors: | , |
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Format: | Article |
Language: | English |
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SAGE Publishing
1995-07-01
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Series: | Cell Transplantation |
Online Access: | https://doi.org/10.1177/096368979500400407 |
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author | Ronald G. Gill Leslie Wolf |
author_facet | Ronald G. Gill Leslie Wolf |
author_sort | Ronald G. Gill |
collection | DOAJ |
description | The goal of cellular transplantation is to allow long-term function of the grafted cells using minimal host immunosuppression. To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immunoisolation technologies to prevent host sensitization to implanted cells; and (iii) the induction of immunological tolerance to the donor tissues. Further, a major dilemma facing clinical tissue grafting is the shortage of donor tissue for transplantation. This problem requires the consideration of tissues from other species (xenografts) as a potential source of donor material. In light of these issues, the focus of this discussion is on the T cell-dependent response to allogeneic and xenogeneic transplants and the implications of this reactivity on the field of cellular replacement therapy. |
first_indexed | 2024-12-10T14:20:18Z |
format | Article |
id | doaj.art-9269708329dc4741ab5c8e731ce128d5 |
institution | Directory Open Access Journal |
issn | 0963-6897 1555-3892 |
language | English |
last_indexed | 2024-12-10T14:20:18Z |
publishDate | 1995-07-01 |
publisher | SAGE Publishing |
record_format | Article |
series | Cell Transplantation |
spelling | doaj.art-9269708329dc4741ab5c8e731ce128d52022-12-22T01:45:13ZengSAGE PublishingCell Transplantation0963-68971555-38921995-07-01410.1177/096368979500400407Immunobiology of Cellular TransplantationRonald G. Gill0Leslie Wolf1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO 80262Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO 80262The goal of cellular transplantation is to allow long-term function of the grafted cells using minimal host immunosuppression. To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immunoisolation technologies to prevent host sensitization to implanted cells; and (iii) the induction of immunological tolerance to the donor tissues. Further, a major dilemma facing clinical tissue grafting is the shortage of donor tissue for transplantation. This problem requires the consideration of tissues from other species (xenografts) as a potential source of donor material. In light of these issues, the focus of this discussion is on the T cell-dependent response to allogeneic and xenogeneic transplants and the implications of this reactivity on the field of cellular replacement therapy.https://doi.org/10.1177/096368979500400407 |
spellingShingle | Ronald G. Gill Leslie Wolf Immunobiology of Cellular Transplantation Cell Transplantation |
title | Immunobiology of Cellular Transplantation |
title_full | Immunobiology of Cellular Transplantation |
title_fullStr | Immunobiology of Cellular Transplantation |
title_full_unstemmed | Immunobiology of Cellular Transplantation |
title_short | Immunobiology of Cellular Transplantation |
title_sort | immunobiology of cellular transplantation |
url | https://doi.org/10.1177/096368979500400407 |
work_keys_str_mv | AT ronaldggill immunobiologyofcellulartransplantation AT lesliewolf immunobiologyofcellulartransplantation |