Immunobiology of Cellular Transplantation

The goal of cellular transplantation is to allow long-term function of the grafted cells using minimal host immunosuppression. To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immuno...

Full description

Bibliographic Details
Main Authors: Ronald G. Gill, Leslie Wolf
Format: Article
Language:English
Published: SAGE Publishing 1995-07-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368979500400407
_version_ 1818063450675347456
author Ronald G. Gill
Leslie Wolf
author_facet Ronald G. Gill
Leslie Wolf
author_sort Ronald G. Gill
collection DOAJ
description The goal of cellular transplantation is to allow long-term function of the grafted cells using minimal host immunosuppression. To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immunoisolation technologies to prevent host sensitization to implanted cells; and (iii) the induction of immunological tolerance to the donor tissues. Further, a major dilemma facing clinical tissue grafting is the shortage of donor tissue for transplantation. This problem requires the consideration of tissues from other species (xenografts) as a potential source of donor material. In light of these issues, the focus of this discussion is on the T cell-dependent response to allogeneic and xenogeneic transplants and the implications of this reactivity on the field of cellular replacement therapy.
first_indexed 2024-12-10T14:20:18Z
format Article
id doaj.art-9269708329dc4741ab5c8e731ce128d5
institution Directory Open Access Journal
issn 0963-6897
1555-3892
language English
last_indexed 2024-12-10T14:20:18Z
publishDate 1995-07-01
publisher SAGE Publishing
record_format Article
series Cell Transplantation
spelling doaj.art-9269708329dc4741ab5c8e731ce128d52022-12-22T01:45:13ZengSAGE PublishingCell Transplantation0963-68971555-38921995-07-01410.1177/096368979500400407Immunobiology of Cellular TransplantationRonald G. Gill0Leslie Wolf1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO 80262Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box B140, Denver, CO 80262The goal of cellular transplantation is to allow long-term function of the grafted cells using minimal host immunosuppression. To this end, the major strategies to implant cells and tissues are through: (i) the pretreatment of the graft to reduce tissue immunogenicity; (ii) the application of immunoisolation technologies to prevent host sensitization to implanted cells; and (iii) the induction of immunological tolerance to the donor tissues. Further, a major dilemma facing clinical tissue grafting is the shortage of donor tissue for transplantation. This problem requires the consideration of tissues from other species (xenografts) as a potential source of donor material. In light of these issues, the focus of this discussion is on the T cell-dependent response to allogeneic and xenogeneic transplants and the implications of this reactivity on the field of cellular replacement therapy.https://doi.org/10.1177/096368979500400407
spellingShingle Ronald G. Gill
Leslie Wolf
Immunobiology of Cellular Transplantation
Cell Transplantation
title Immunobiology of Cellular Transplantation
title_full Immunobiology of Cellular Transplantation
title_fullStr Immunobiology of Cellular Transplantation
title_full_unstemmed Immunobiology of Cellular Transplantation
title_short Immunobiology of Cellular Transplantation
title_sort immunobiology of cellular transplantation
url https://doi.org/10.1177/096368979500400407
work_keys_str_mv AT ronaldggill immunobiologyofcellulartransplantation
AT lesliewolf immunobiologyofcellulartransplantation