Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling

Severe Acute Respiratory Syndrome Coronavirus 2 ORF8 Protein Inhibits Type I Interferon Production by Targeting HSP90B1 Signaling

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that has currently infected over 430 million individuals worldwide. With the variant strains of SARS-CoV-2 emerging, a region of high mutation rates in ORF8 was identifie...

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Bibliographic Details
Main Authors: Jiayi Chen, Zixin Lu, Xiuwen Yang, Yezhen Zhou, Jing Gao, Shihao Zhang, Shan Huang, Jintai Cai, Jianhai Yu, Wei Zhao, Bao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
ORF8 protein
type I interferon
HSP90B1
IRF3
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.899546/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.899546/full

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