IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche
The adult subventricular zone (SVZ) is the main neurogenic niche in normal adult brains of mice and rats. Interferon gamma (IFNγ) has somewhat controversially been associated with SVZ progenitor proliferation and neurogenesis. The in vivo involvement of IFNγ in the physiology of the adult SVZ niche...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00270/full |
| _version_ | 1818497818228162560 |
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| author | Leticia Pereira Gómez Leticia Pereira Gómez Rebeca eMedina Rebeca eMedina Miguel eBaena Miguel eBaena Anna Maria Planas Anna Maria Planas Esther ePozas Esther ePozas |
| author_facet | Leticia Pereira Gómez Leticia Pereira Gómez Rebeca eMedina Rebeca eMedina Miguel eBaena Miguel eBaena Anna Maria Planas Anna Maria Planas Esther ePozas Esther ePozas |
| author_sort | Leticia Pereira Gómez |
| collection | DOAJ |
| description | The adult subventricular zone (SVZ) is the main neurogenic niche in normal adult brains of mice and rats. Interferon gamma (IFNγ) has somewhat controversially been associated with SVZ progenitor proliferation and neurogenesis. The in vivo involvement of IFNγ in the physiology of the adult SVZ niche is not fully understood and its intracellular mediators are unknown. Here we show that IFNγ, through activation of its canonical STAT1 pathway, acts specifically on Nestin+ progenitors by decreasing both progenitor proliferation and the number of cycling cells. In addition, IFNγ increases the number of neuroblasts generated without shifting glial fate determination. The final result is deficient recruitment of newborn neurons to the olfactory bulb, indicating that IFNγ-induced stimulation of neuronal differentiation does not compensate for its antiproliferative effect. We conclude that IFNγ signaling via STAT1 in the SVZ acts dually as an antiproliferative and proneurogenic factor, and thereby regulates neurogenesis in normal adult brains. |
| first_indexed | 2024-12-10T18:50:07Z |
| format | Article |
| id | doaj.art-9271f65b9449428fa05fe99122853a5d |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T18:50:07Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9271f65b9449428fa05fe99122853a5d2022-12-22T01:37:21ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-07-01910.3389/fncel.2015.00270151881IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ nicheLeticia Pereira Gómez0Leticia Pereira Gómez1Rebeca eMedina2Rebeca eMedina3Miguel eBaena4Miguel eBaena5Anna Maria Planas6Anna Maria Planas7Esther ePozas8Esther ePozas9IDIBAPSConsejo Superior de Investigaciones Científicas, CSICIDIBAPSConsejo Superior de Investigaciones Científicas, CSICIDIBAPSConsejo Superior de Investigaciones Científicas, CSICIDIBAPSConsejo Superior de Investigaciones Científicas, CSICIDIBAPSConsejo Superior de Investigaciones Científicas, CSICThe adult subventricular zone (SVZ) is the main neurogenic niche in normal adult brains of mice and rats. Interferon gamma (IFNγ) has somewhat controversially been associated with SVZ progenitor proliferation and neurogenesis. The in vivo involvement of IFNγ in the physiology of the adult SVZ niche is not fully understood and its intracellular mediators are unknown. Here we show that IFNγ, through activation of its canonical STAT1 pathway, acts specifically on Nestin+ progenitors by decreasing both progenitor proliferation and the number of cycling cells. In addition, IFNγ increases the number of neuroblasts generated without shifting glial fate determination. The final result is deficient recruitment of newborn neurons to the olfactory bulb, indicating that IFNγ-induced stimulation of neuronal differentiation does not compensate for its antiproliferative effect. We conclude that IFNγ signaling via STAT1 in the SVZ acts dually as an antiproliferative and proneurogenic factor, and thereby regulates neurogenesis in normal adult brains.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00270/fullNeurogenesisSTAT1differentiationSVZIFNγ |
| spellingShingle | Leticia Pereira Gómez Leticia Pereira Gómez Rebeca eMedina Rebeca eMedina Miguel eBaena Miguel eBaena Anna Maria Planas Anna Maria Planas Esther ePozas Esther ePozas IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche Frontiers in Cellular Neuroscience Neurogenesis STAT1 differentiation SVZ IFNγ |
| title | IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche |
| title_full | IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche |
| title_fullStr | IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche |
| title_full_unstemmed | IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche |
| title_short | IFN gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche |
| title_sort | ifn gamma regulates proliferation and neuronal differentiation by stat1 in adult svz niche |
| topic | Neurogenesis STAT1 differentiation SVZ IFNγ |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00270/full |
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