Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model

Abstract The present study explores the avenue of phage therapy as an alternative antimicrobial therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa infection. Our study investigated two novel virulent phages PSPa and APPa, specific to P. aeruginosa, in which in vitro eva...

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Bibliographic Details
Main Authors: Chandrasekar Karthika, Nambiraman Malligarjunan, Ravi Jothi, Thirupathi Kasthuri, Rajaiah Alexpandi, Arumugam Veera Ravi, Shunmugiah Karutha Pandian, Shanmugaraj Gowrishankar
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45313-x