Molecular Surveillance of Antimicrobial Resistance of Mycobacterium leprae from Leprosy Patients in Zhejiang Province, China

Molecular Surveillance of Antimicrobial Resistance of Mycobacterium leprae from Leprosy Patients in Zhejiang Province, China

Ying Shi1– 3*, Wenming Kong1 *, Haiqin Jiang,2,3 Wenyue Zhang,2,3 Chen Wang,2– 4 Limei Wu,1 Yunliang Shen,1 Qiang Yao,1 Hongsheng Wang1– 3,5 1Department of Leprosy Control, Zhejiang Provincial Institute of Dermatology, Huzhou, People’s Republic of China; 2Hospital of Skin Diseases, I...

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Bibliographic Details
Main Authors: Shi Y, Kong W, Jiang H, Zhang W, Wang C, Wu L, Shen Y, Yao Q, Wang H
Format: Article
Language:English
Published: Dove Medical Press 2022-07-01
Series:Infection and Drug Resistance
Subjects:
purpose: reports on antimicrobial resistance (amr) of mycobacterium leprae (m. leprae) in zhejiang province are limited. thus
this study aimed to investigate the drug resistance of new leprosy cases within several years and analyse the emergence of amr mutations from zhejiang province. methods: this study enrolled 34 leprosy cases in zhejiang province
china
from 2018 to 2021. gene mutation of who-recommended drdrs (folp1
rpob and gyra) and genes of compensatory amr-associated drdrs
including nth
rpoa
rpoc
gyrb and 23s rrna
were detected by amplification. clinical data analysis was performed to investigate the epidemiological association of leprosy. results: of the 34 samples
two (5.9%) strains showed drug resistance
which were mutated to dapsone and ofloxacin
separately. two single mutations in gyrb were detected in different strains (5.9%)
whereas one of the rpoc mutation was also detected in one strain each (2.9%)
which were proved to be polymorphs. no correlation of drug resistance proportion was identified in male vs. female
nerve vs. no nerve involvement
deformity vs. no deformity and reaction vs. non-reaction cases. conclusion: results showed well control of leprosy patients in zhejiang province. gene mutations of who-recommended drdrs folp1 and gyra confirmed the resistance to dapsone and ofloxacin. compensatory amr-associated mutations confirmed to be polymorphs still require further study to determine their phenotypic outcomes in m. leprae. the results demonstrated that drug-resistant strains are not epidemic in this area. given the few cases of leprosy
analysing the amr of m. leprae in zhejiang province more comprehensively is difficult. however
regular mdt treatment and population management in the early stage may contribute to the low prevalence of leprosy.
Online Access:https://www.dovepress.com/molecular-surveillance-of-antimicrobial-resistance-of-mycobacterium-le-peer-reviewed-fulltext-article-IDR

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