Cell‐to‐cell variability of alternative RNA splicing

Abstract Heterogeneity in the expression levels of mammalian genes is large even in clonal populations and has phenotypic consequences. Alternative splicing is a fundamental aspect of gene expression, yet its contribution to heterogeneity is unknown. Here, we use single‐molecule imaging to character...

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Bibliographic Details
Main Authors: Zeev Waks, Allon M Klein, Pamela A Silver
Format: Article
Language:English
Published: Springer Nature 2011-07-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.1038/msb.2011.32