Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush

Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush

Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve regeneration. However, morphological assessments of retinorecipient regions are limited by the opacity of brain tissue. In this study, we used an innovative tis...

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Bibliographic Details
Main Authors: Zong-Yi Zhan, Yi-Ru Huang, Lu-Wei Zhao, Ya-Dan Quan, Zi-Jing Li, Di-Fang Sun, Ya-Li Wu, Hao-Yuan Wu, Zi-Tian Liu, Kai-Li Wu, Yu-Qing Lan, Min-Bin Yu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
histology; image analysis; light-sheet imaging; optic nerve crush; pseudorabies virus; retinal ganglion cells; three-dimensional imaging; tissue clearing; viral tracing; whole brain study
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=4;spage=913;epage=921;aulast=Zhan

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=4;spage=913;epage=921;aulast=Zhan

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