The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

The precise regulation of microtubule dynamics is essential during cell division. The kinesin-13 motor protein MCAK is a potent microtubule depolymerase. The divergent non-motor regions flanking the ATPase domain are critical in regulating its targeting and activity. However, the molecular basis for...

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Bibliographic Details
Main Authors: Sandeep K Talapatra, Bethany Harker, Julie PI Welburn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
kinesin
X-ray crystallography
tubulin
microtubule depolymerization
structure
homo sapien
Online Access:https://elifesciences.org/articles/06421

Internet

https://elifesciences.org/articles/06421

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