Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis

Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis

ABSTRACT This analysis assessed the relationship between the plasma concentrations of loperamide and its N‐desmethyl loperamide meta‐ bolite (M1) and the potential QT interval prolongation at therapeutic and supratherapeutic doses. The exposure–response analysis was performed using the data from hea...

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Bibliographic Details
Main Authors: Belén Valenzuela, Per Olsson Gisleskog, Iolanda Cirillo, Erwin Coenen, Jay Ariyawansa, Saberi Rana Ali, Samiha Takhtoukh, Juan José Pérez‐Ruixo, Oliver Ackaert
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Science
Subjects:
cardiology
drug development
modeling and simulation
pharmacokinetics
phase 1
QTc prolongation
Online Access:https://doi.org/10.1111/cts.70114

Internet

https://doi.org/10.1111/cts.70114

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