In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator

In Silico Identification and Experimental Validation of (−)-Muqubilin A, a Marine Norterpene Peroxide, as PPARα/γ-RXRα Agonist and RARα Positive Allosteric Modulator

The nuclear receptors (NRs) RARα, RXRα, PPARα, and PPARγ represent promising pharmacological targets for the treatment of neurodegenerative diseases. In the search for molecules able to simultaneously target all the above-mentioned NRs, we screened an in-house dev...

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Bibliographic Details
Main Authors: Enrico D’Aniello, Fabio Arturo Iannotti, Lauren G. Falkenberg, Andrea Martella, Alessandra Gentile, Fabrizia De Maio, Maria Letizia Ciavatta, Margherita Gavagnin, Joshua S. Waxman, Vincenzo Di Marzo, Pietro Amodeo, Rosa Maria Vitale
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Marine Drugs
Subjects:
virtual screening
nuclear receptor agonist
positive allosteric modulator
zebrafish models
Online Access:https://www.mdpi.com/1660-3397/17/2/110

Internet

https://www.mdpi.com/1660-3397/17/2/110

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