Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome

Hyperuricaemia Does Not Interfere with Aortopathy in a Murine Model of Marfan Syndrome

Redox stress is involved in the aortic aneurysm pathogenesis in Marfan syndrome (MFS). We recently reported that allopurinol, a xanthine oxidoreductase inhibitor, blocked aortopathy in a MFS mouse model acting as an antioxidant without altering uric acid (UA) plasma levels. Hyperuricaemia is ambiguo...

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Bibliographic Details
Main Authors: Isaac Rodríguez-Rovira, Angela López-Sainz, Maria Encarnación Palomo-Buitrago, Belen Pérez, Francesc Jiménez-Altayó, Victoria Campuzano, Gustavo Egea
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
uric acid
aortic aneurysm
Marfan syndrome
allopurinol
oxidative stress
oxonic acid
Online Access:https://www.mdpi.com/1422-0067/24/14/11293

Internet

https://www.mdpi.com/1422-0067/24/14/11293

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