Targeting Pro-Survival Autophagy Enhanced GSK-3β Inhibition-Induced Apoptosis and Retarded Proliferation in Bladder Cancer Cells

Targeting Pro-Survival Autophagy Enhanced GSK-3β Inhibition-Induced Apoptosis and Retarded Proliferation in Bladder Cancer Cells

Advanced bladder cancer (BC) (local invasive and/or metastatic) is not curable even with cytotoxic chemotherapy, immune checkpoint inhibitors, and targeted treatment. Targeting GSK-3β is a promising novel approach in advanced BC. The induction of autophagy is a mechanism of secondary resistance to v...

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Bibliographic Details
Main Authors: Yuko Shirono, Vladimir Bilim, Tsutomu Anraku, Hiroo Kuroki, Akira Kazama, Masaki Murata, Kaede Hiruma, Yoshihiko Tomita
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Current Oncology
Subjects:
AMPK
autophagy
bladder cancer
GSK-3β
LC3B
TFEB
Online Access:https://www.mdpi.com/1718-7729/30/6/406

Internet

https://www.mdpi.com/1718-7729/30/6/406

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