Separate-component-stabilization system for protein and DNA production without the use of antibiotics

Plasmid instability is a significant concern in the industrial utilization of microorganisms for protein or DNA production. Here we report on the development of a new and highly effective stabilization system based on the use of the ccd antidote/poison genes. For the first time, we separated the ant...

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Bibliographic Details
Main Authors: Cédric Y. Szpirer, Michel C. Milinkovitch
Format: Article
Language:English
Published: Taylor & Francis Group 2005-05-01
Series:BioTechniques
Online Access:https://www.future-science.com/doi/10.2144/05385RR02