An influenza A/H1N1/2009 hemagglutinin vaccine produced in Escherichia coli.

The A/H1N1/2009 influenza pandemic made evident the need for faster and higher-yield methods for the production of influenza vaccines. Platforms based on virus culture in mammalian or insect cells are currently under investigation. Alternatively, expression of fragments of the hemagglutinin (HA) pro...

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Main Authors: José M Aguilar-Yáñez, Roberto Portillo-Lara, Gonzalo I Mendoza-Ochoa, Sergio A García-Echauri, Felipe López-Pacheco, David Bulnes-Abundis, Johari Salgado-Gallegos, Itzel M Lara-Mayorga, Yenny Webb-Vargas, Felipe O León-Angel, Ramón E Rivero-Aranda, Yuriana Oropeza-Almazán, Guillermo M Ruiz-Palacios, Manuel I Zertuche-Guerra, Rebecca M DuBois, Stephen W White, Stacey Schultz-Cherry, Charles J Russell, Mario M Alvarez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2908544?pdf=render