Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Removal of the C-Terminal Domains of ADAMTS13 by Activated Coagulation Factor XI induces Platelet Adhesion on Endothelial Cells under Flow Conditions

Platelet recruitment to sites of vascular injury is mediated by von Willebrand factor (VWF). The shear-induced unraveling of ultra-large VWF multimers causes the formation of a “stringlike” conformation, which rapidly recruits platelets from the bloodstream. A disintegrin and metalloproteinase with...

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Bibliographic Details
Main Authors: Kathleen S. Garland, Stéphanie E. Reitsma, Toshiaki Shirai, Jevgenia Zilberman-Rudenko, Erik I. Tucker, David Gailani, András Gruber, Owen J. T. McCarty, Cristina Puy
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Medicine
Subjects:
a disintegrin and metalloproteinase with a thrombospondin type 1 motif
member 13
factor XI
coagulation
von Willebrand factor
platelets
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2017.00232/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2017.00232/full

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