C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys

C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys

Poly(PR) is a dipeptide repeat protein comprising proline and arginine residues. It is one of the translational product of expanded G4C2 repeats in the C9orf72 gene, and its accumulation is contributing to the neuropathogenesis of C9orf72-associated amyotrophic lateral sclerosis and/or frontotempora...

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Bibliographic Details
Main Authors: Lizhu Xu, Dan Wang, Lu Zhao, Zhengsheng Yang, Xu Liu, Xinyue Li, Tingli Yuan, Ye Wang, Tianzhuang Huang, Ning Bian, Yuqun He, Xinglong Chen, Baohong Tian, Zexian Liu, Fucheng Luo, Wei Si, Guangping Gao, Weizhi Ji, Yuyu Niu, Jingkuan Wei
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
ALS
C9orf72
Poly(PR)
CHIT1
cynomolgus monkeys
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002127

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http://www.sciencedirect.com/science/article/pii/S0969996123002127

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