Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance

Chimeric Antigen Receptor T Cell Therapy Targeting Epithelial Cell Adhesion Molecule in Gastric Cancer: Mechanisms of Tumor Resistance

Epithelial cell adhesion molecule (EpCAM) is a tumor-associated antigen that is frequently overexpressed in various carcinomas. We have developed chimeric antigen receptor (CAR) T cells specifically targeting EpCAM for the treatment of gastric cancer. This study sought to unravel the precise mechani...

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Bibliographic Details
Main Authors: Yanping Yang, Raymond Louie, Janusz Puc, Yogindra Vedvyas, Yago Alcaina, Irene M. Min, Matt Britz, Fabio Luciani, Moonsoo M. Jin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
CAR T cell therapy
EpCAM
single-cell multiomics
CAR T cell imaging
Online Access:https://www.mdpi.com/2072-6694/15/23/5552

Internet

https://www.mdpi.com/2072-6694/15/23/5552

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