Review of the epidemiology and variability of LRRK2 non-p.Gly2019Ser pathogenic mutations in Parkinson’s disease

Review of the epidemiology and variability of LRRK2 non-p.Gly2019Ser pathogenic mutations in Parkinson’s disease

Parkinson’s disease (PD) is a heterogenous neurodegenerative disorder. Genetic factors play a significant role, especially in early onset and familial cases. Mutations are usually found in the LRRK2 gene, but their importance varies. Some mutations, such as p.Arg1441Cys or other alterations in the 1...

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Bibliographic Details
Main Authors: Paweł Turski, Iwona Chaberska, Piotr Szukało, Paulina Pyska, Łukasz Milanowski, Stanisław Szlufik, Monika Figura, Dorota Hoffman-Zacharska, Joanna Siuda, Dariusz Koziorowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neuroscience
Subjects:
LRRK2
Parkinson’s disease
epidemiology
pathogenic variants
p.Asn1437His
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.971270/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.971270/full

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