RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

Summary: Homologous recombination (HR) protects replication forks (RFs) and repairs DNA double-strand breaks (DSBs). Within HR, BRCA2 regulates RAD51 via two interaction regions: the BRC repeats to form filaments on single-stranded DNA and exon 27 (Ex27) to stabilize the filament. Here, we identifie...

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Bibliographic Details
Main Authors: Mi Young Son, Ondrej Belan, Mario Spirek, Jakub Cibulka, Fedor Nikulenkov, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Cristina Montagna, Tae Moon Kim, Lumir Krejci, Paul Hasty
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Properties of biomolecules
Genetics
Molecular biology
Molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224007454

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http://www.sciencedirect.com/science/article/pii/S2589004224007454

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