Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury

Simultaneous targeting of mitochondria and monocytes enhances neuroprotection against ischemia–reperfusion injury

Abstract Ischemia–reperfusion injury impairs the efficacy of reperfusion therapy after ischemic stroke. Cyclophilin D (CypD)-mediated openings of mitochondrial permeability transition pore (mPTP) and subsequent monocyte-mediated inflammation are considered as major mechanisms of reperfusion injury....

Full description

Bibliographic Details
Main Authors: Arihide Okahara, Jun-ichiro Koga, Tetsuya Matoba, Masaki Fujiwara, Masaki Tokutome, Gentaro Ikeda, Kaku Nakano, Masaki Tachibana, Tetsuro Ago, Takanari Kitazono, Hiroyuki Tsutsui, Kensuke Egashira
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-71326-x

Internet

https://doi.org/10.1038/s41598-020-71326-x

Similar Items