Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy

Immunogenicity of Novel AAV Capsids for Retinal Gene Therapy

Objectives: AAV vectors are widely used in gene therapy, but the prevalence of neutralizing antibodies raised against AAV serotypes in the course of a natural infection, as well as innate and adaptive immune responses induced upon vector administration, is still considered an important limitation. I...

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Bibliographic Details
Main Authors: Miranda Gehrke, Maria Diedrichs-Möhring, Jacqueline Bogedein, Hildegard Büning, Stylianos Michalakis, Gerhild Wildner
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
antibodies
neutralization
cellular immunity
innate immunity
adaptive immunity
monocyte-derived DC
Online Access:https://www.mdpi.com/2073-4409/11/12/1881

Internet

https://www.mdpi.com/2073-4409/11/12/1881

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