The lncRNA CASC2 Modulates Hepatocellular Carcinoma Cell Sensitivity and Resistance to TRAIL Through Apoptotic and Non-Apoptotic Signaling

The lncRNA CASC2 Modulates Hepatocellular Carcinoma Cell Sensitivity and Resistance to TRAIL Through Apoptotic and Non-Apoptotic Signaling

The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been widely concerned as a tumor therapy because of its ability of selective triggering cancer cell apoptosis; nevertheless, hepatocellular carcinoma (HCC) exhibits acquired resistance to TRAIL-induced apoptosis....

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Bibliographic Details
Main Authors: Jichun Sun, Hongbo Xu, Zhao Lei, Zhiqiang Li, Hongwei Zhu, Zhen Deng, Xiao Yu, Xiaoxin Jin, Zhi Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
TNF-related apoptosis-inducing ligand (TRAIL)
lncRNA CASC2
miR-18a
receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
the NF-κB signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.726622/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.726622/full

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