Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
A fraction of mammalian CTCF binding sites fall within transposable elements (TEs) but their contribution to the evolution of 3D chromatin structure is unknown. Here the authors investigate the effect of TE-driven CTCF binding site expansions on chromatin looping in humans and mice, and provide evid...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15520-5 |