Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, decompensation, and development of hepatocel...

Full description

Bibliographic Details
Main Authors: Jane I. Grove, Peggy C.K. Lo, Nick Shrine, Julian Barwell, Louise V. Wain, Martin D. Tobin, Andrew M. Salter, Aditi N. Borkar, Sara Cuevas-Ocaña, Neil Bennett, Catherine John, Ioanna Ntalla, Gabriela E. Jones, Christopher P. Neal, Mervyn G. Thomas, Helen Kuht, Pankaj Gupta, Vishwaraj M. Vemala, Allister Grant, Adeolu B. Adewoye, Kotacherry T. Shenoy, Leena K. Balakumaran, Edward J. Hollox, Nicholas R.F. Hannan, Guruprasad P. Aithal
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:JHEP Reports
Subjects:
Microsomal triglyceride transfer protein
Abetalipoproteinaemia
hiPSC-derived hepatocytes
Lipoprotein ApoB
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555923000952

Internet

http://www.sciencedirect.com/science/article/pii/S2589555923000952

Similar Items