THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B
Chronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic mechanisms. One of the key mechanisms in epigenetics...
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| Format: | Article |
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Central Research Institute for Epidemiology
2018-02-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/180/90 |
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| author | D. S. Kostyushev A. P. Zueva S. A. Brezgin A. D. Lipatnikov E. V. Volchkova V. V. Maleyev V. P. Chulanov |
| author_facet | D. S. Kostyushev A. P. Zueva S. A. Brezgin A. D. Lipatnikov E. V. Volchkova V. V. Maleyev V. P. Chulanov |
| author_sort | D. S. Kostyushev |
| collection | DOAJ |
| description | Chronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic mechanisms. One of the key mechanisms in epigenetics is methylation of DNA on CpG islands. Expression levels of DNA-methyltransferases (DNMTs) in chronic hepatitis B patients were shown to be upregulated. Nevertheless, the role of DNMTs in the life cycle of HBV and their effects on the cell remain elusive. In this review, we discuss latest achievements on the role of DNMTs in chronic hepatitis B and HBV in vitro models. |
| first_indexed | 2024-03-13T00:08:51Z |
| format | Article |
| id | doaj.art-92a5f3688edd4594be3bf399a8b51f67 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:08:51Z |
| publishDate | 2018-02-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-92a5f3688edd4594be3bf399a8b51f672023-07-12T20:00:39ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972018-02-01631192910.18821/0507-4088-2018-63-1-19-29160THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS BD. S. Kostyushev0A. P. Zueva1S. A. Brezgin2A. D. Lipatnikov3E. V. Volchkova4V. V. Maleyev5V. P. Chulanov6Central Research Institute of EpidemiologyCentral Research Institute of EpidemiologyCentral Research Institute of EpidemiologyCentral Research Institute of EpidemiologyI.M. Sechenov First State Medical UniversityCentral Research Institute of EpidemiologyCentral Research Institute of EpidemiologyChronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic mechanisms. One of the key mechanisms in epigenetics is methylation of DNA on CpG islands. Expression levels of DNA-methyltransferases (DNMTs) in chronic hepatitis B patients were shown to be upregulated. Nevertheless, the role of DNMTs in the life cycle of HBV and their effects on the cell remain elusive. In this review, we discuss latest achievements on the role of DNMTs in chronic hepatitis B and HBV in vitro models.https://virusjour.crie.ru/jour/article/viewFile/180/90hepatitis b viruschronic hepatitis bdna-methyltransferasesγ-h2axtranscriptionhbsagmethylationgenotypes |
| spellingShingle | D. S. Kostyushev A. P. Zueva S. A. Brezgin A. D. Lipatnikov E. V. Volchkova V. V. Maleyev V. P. Chulanov THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B Вопросы вирусологии hepatitis b virus chronic hepatitis b dna-methyltransferases γ-h2ax transcription hbsag methylation genotypes |
| title | THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B |
| title_full | THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B |
| title_fullStr | THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B |
| title_full_unstemmed | THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B |
| title_short | THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B |
| title_sort | role of dna methyltransferases in the life cycle of hepatitis b virus and pathogenesis of chronic hepatitis b |
| topic | hepatitis b virus chronic hepatitis b dna-methyltransferases γ-h2ax transcription hbsag methylation genotypes |
| url | https://virusjour.crie.ru/jour/article/viewFile/180/90 |
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