Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function
Autotransporters are bacterial proteins that possess multiple activities associated with pathogenesis. Here the authors present the structure of the autotransporter subtilase Ssp from Serratia marcescens and show that its distinctive structural features are required for its cytotoxic function.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36719-2 |
| _version_ | 1827983433786195968 |
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| author | Lilian Hor Akila Pilapitiya James A. McKenna Santosh Panjikar Marilyn A. Anderson Mickaël Desvaux Jason J. Paxman Begoña Heras |
| author_facet | Lilian Hor Akila Pilapitiya James A. McKenna Santosh Panjikar Marilyn A. Anderson Mickaël Desvaux Jason J. Paxman Begoña Heras |
| author_sort | Lilian Hor |
| collection | DOAJ |
| description | Autotransporters are bacterial proteins that possess multiple activities associated with pathogenesis. Here the authors present the structure of the autotransporter subtilase Ssp from Serratia marcescens and show that its distinctive structural features are required for its cytotoxic function. |
| first_indexed | 2024-04-09T22:48:23Z |
| format | Article |
| id | doaj.art-92aa96900898463092e56bee5126bdf0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:48:23Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-92aa96900898463092e56bee5126bdf02023-03-22T11:45:28ZengNature PortfolioNature Communications2041-17232023-03-0114111310.1038/s41467-023-36719-2Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic functionLilian Hor0Akila Pilapitiya1James A. McKenna2Santosh Panjikar3Marilyn A. Anderson4Mickaël Desvaux5Jason J. Paxman6Begoña Heras7Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe UniversityDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe UniversityDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe UniversityAustralian Synchrotron, ANSTODepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe UniversityINRAE, Université Clermont Auvergne, UMR454 MEDiSDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe UniversityDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe UniversityAutotransporters are bacterial proteins that possess multiple activities associated with pathogenesis. Here the authors present the structure of the autotransporter subtilase Ssp from Serratia marcescens and show that its distinctive structural features are required for its cytotoxic function.https://doi.org/10.1038/s41467-023-36719-2 |
| spellingShingle | Lilian Hor Akila Pilapitiya James A. McKenna Santosh Panjikar Marilyn A. Anderson Mickaël Desvaux Jason J. Paxman Begoña Heras Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function Nature Communications |
| title | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function |
| title_full | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function |
| title_fullStr | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function |
| title_full_unstemmed | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function |
| title_short | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function |
| title_sort | crystal structure of a subtilisin like autotransporter passenger domain reveals insights into its cytotoxic function |
| url | https://doi.org/10.1038/s41467-023-36719-2 |
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