Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function
Autotransporters are bacterial proteins that possess multiple activities associated with pathogenesis. Here the authors present the structure of the autotransporter subtilase Ssp from Serratia marcescens and show that its distinctive structural features are required for its cytotoxic function.
Main Authors: | Lilian Hor, Akila Pilapitiya, James A. McKenna, Santosh Panjikar, Marilyn A. Anderson, Mickaël Desvaux, Jason J. Paxman, Begoña Heras |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-36719-2 |
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