Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing

Abstract Background Analysis of melanomas for actionable mutations has become the standard of care. Recently, a classification scheme has been proposed that categorizes BRAF mutations based on their mechanisms for activation of the MAPK pathway. Methods In this analysis BRAF, KIT, NRAS, and PIK3CA m...

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Bibliographic Details
Main Authors: Parvez M. Lokhandwala, Li-Hui Tseng, Erika Rodriguez, Gang Zheng, Aparna Pallavajjalla, Christopher D. Gocke, James R. Eshleman, Ming-Tseh Lin
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
BRAF
NRAS
Melanoma
Kinase-impaired
Categorization
Online Access:http://link.springer.com/article/10.1186/s12885-019-5864-1

Internet

http://link.springer.com/article/10.1186/s12885-019-5864-1

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