Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis

Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis

Objectives Almost all patients with systemic sclerosis (SSc) harbour autoantibodies. Anti-topoisomerase antibodies (ATA) and anti-centromere antibodies (ACA) are most prevalent and associate with distinct clinical phenotypes. B cell responses underlying these phenotypes are ill-defined. To understan...

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Bibliographic Details
Main Authors: Jeska De Vries-Bouwstra, Tom WJ Huizinga, René EM Toes, Hans U Scherer, Maaike Boonstra, Cynthia M Fehres, Corrie M Wortel, Sophie IE Liem, Nina M van Leeuwen, Lauran Stöger
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/9/3/e003148.full

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https://rmdopen.bmj.com/content/9/3/e003148.full

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