Characterization and Antiproliferative Activity of a Novel 2-Aminothiophene Derivative-β-Cyclodextrin Binary System

Characterization and Antiproliferative Activity of a Novel 2-Aminothiophene Derivative-β-Cyclodextrin Binary System

The novel 2-aminothiophene derivative 2-amino-4,5,6,7-tetrahydrobenzo[<i>b</i>]thiophene-3-carbonitrile (6CN) has shown potential anti-proliferative activity in human cancer cell lines. However, the poor aqueous solubility of 6CN impairs its clinical use. This work aimed to develop binar...

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Bibliographic Details
Main Authors: Elayne Barros Ferreira, Walter Ferreira da Silva Júnior, Jonas Gabriel de Oliveira Pinheiro, Aldilane Gonçalves da Fonseca, Telma Maria Araújo Moura Lemos, Hugo Alexandre de Oliveira Rocha, Eduardo Pereira de Azevedo, Francisco Jaime Bezerra Mendonça Junior, Ádley Antonini Neves de Lima
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
2-aminothiophene derivative
β-cyclodextrin
antitumor
anti-proliferative
cytostatic
Online Access:https://www.mdpi.com/1420-3049/23/12/3130

Internet

https://www.mdpi.com/1420-3049/23/12/3130

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