Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis

Fractionated alpha and mixed beam radiation promote stronger pro-inflammatory effects compared to acute exposure and trigger phagocytosis

Introduction and methodsAiming to evaluate safety aspects of a recently proposed approach to target Alzheimer’s disease, we mimicked a complex boron neutron capture therapy field using a mixed beam consisting of high- and low-linear energy transfer (LET) radiation, 241Am alpha particles (α) and/or X...

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Bibliographic Details
Main Authors: Mostafa Karimi Roshan, Sergey Belikov, Melissa Ix, Nicoletta Protti, Claudia Balducci, Richard Dodel, J. Alexander Ross, Lovisa Lundholm
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
radiation
microglia
inflammation
DNA damage
cGAS-STING
phagocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1440559/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2024.1440559/full

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