Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth

Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth

Abstract Infants with congenital diaphragmatic hernia (CDH) may require cardiopulmonary bypass and systemic anticoagulation. Expeditious lung growth while on bypass is essential for survival. Previously, we demonstrated that heparin impairs lung growth and function in a murine model of compensatory...

Full description

Bibliographic Details
Main Authors: Savas T. Tsikis, Thomas I. Hirsch, Scott C. Fligor, Amy Pan, Malachi M. Joiner, Angela Devietro, Paul D. Mitchell, Hiroko Kishikawa, Kathleen M. Gura, Mark Puder
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25773-3

Internet

https://doi.org/10.1038/s41598-022-25773-3

Similar Items