Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

Signaling of High Mobility Group Box 1 (HMGB1) through Toll-like Receptor 4 in Macrophages Requires CD14

Abstract High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike, proinflammatory properties when released extracellularly in the C23–C45 disulfide form. HMGB1 also plays a key role as a mediator of acute and chronic inflammation in models of sterile injury. Although H...

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Bibliographic Details
Main Authors: Sodam Kim, Sun Young Kim, John P. Pribis, Michael Lotze, Kevin P. Mollen, Richard Shapiro, Patricia Loughran, Melanie J. Scott, Timothy R. Billiar
Format: Article
Language:English
Published: BMC 2013-03-01
Series:Molecular Medicine
Subjects:
High Mobility Group Box (HMGB1)
TIR-domain-containing Adapter-inducing Interferon-β (TRIF)
HMGB1 Stimulates
Myeloid Differentiation Primary Response Protein
Lipid Rafts
Online Access:https://doi.org/10.2119/molmed.2012.00306

Internet

https://doi.org/10.2119/molmed.2012.00306

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