The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease

The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease

Abstract The main protease of SARS-CoV-2 (Mpro) is an important target for developing COVID-19 therapeutics. Recent work has highlighted Mpro’s susceptibility to undergo redox-associated conformational changes in response to cellular and immune-system-induced oxidation. Despite structural evidence i...

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Bibliographic Details
Main Authors: Norman Tran, Sathish Dasari, Sarah A. E. Barwell, Matthew J. McLeod, Subha Kalyaanamoorthy, Todd Holyoak, Aravindhan Ganesan
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40023-4

Internet

https://doi.org/10.1038/s41467-023-40023-4

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