Acute Promyelocytic Leukemia: Review of Complications Related to All-Trans Retinoic Acid and Arsenic Trioxide Therapy

Acute Promyelocytic Leukemia: Review of Complications Related to All-Trans Retinoic Acid and Arsenic Trioxide Therapy

The hallmark of acute promyelocytic leukemia (APL) is the presence of the characteristic fusion transcript of the promyelocytic leukemia gene with the retinoic acid receptor α gene (PML::RARA). The PML::RARA fusion is a molecular target for all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)....

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Bibliographic Details
Main Authors: Alexandra Ghiaur, Cristina Doran, Mihnea-Alexandru Gaman, Bogdan Ionescu, Aurelia Tatic, Mihaela Cirstea, Maria Camelia Stancioaica, Roxana Hirjan, Daniel Coriu
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cancers
Subjects:
acute promyelocytic leukemia
arsenic trioxide
all-trans retinoic acid
non-hematologic toxicities
Online Access:https://www.mdpi.com/2072-6694/16/6/1160

Internet

https://www.mdpi.com/2072-6694/16/6/1160

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