The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum

The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum

Background: Several SARS-CoV-2 lineages with spike receptor binding domain (RBD) N501Y mutation have spread globally. We evaluated the impact of N501Y on neutralizing activity of COVID-19 convalescent sera and on anti-RBD IgG assays. Methods: The susceptibility to neutralization by COVID-19 patients...

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Bibliographic Details
Main Authors: Lu Lu, Allen Wing-Ho Chu, Ricky Ruiqi Zhang, Wan-Mui Chan, Jonathan Daniel Ip, Hoi-Wah Tsoi, Lin-lei Chen, Jian-Piao Cai, David Christopher Lung, Anthony Raymond Tam, Yat-Sun Yau, Mike Yat-Wah Kwan, Wing-Kin To, Owen Tak-Yin Tsang, Larry Lap-Yip Lee, Haisu Yi, Tak-Chuen Ip, Rosana Wing-Shan Poon, Gilman Kit-Hang Siu, Bobo Wing-Yee Mok, Vincent Chi-Chung Cheng, Kwok Hung Chan, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:EBioMedicine
Subjects:
SARS-CoV-2 N501Y variant B.1.1.7
B.1.351
Neutralizing antibody Spike protein receptor binding domain
VOC
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003376

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http://www.sciencedirect.com/science/article/pii/S2352396421003376

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