Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke

Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke

Stroke patients are at increased risk for recurrent stroke and development of post-stroke dementia. In this study, we investigated the effects of recurrent stroke on adult brain neurogenesis using a novel rat model of recurrent middle cerebral artery occlusion (MCAO) developed in our laboratory. Usi...

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Bibliographic Details
Main Authors: Ruihe Lin, Michael Lang, Nicolette Heinsinger, Geoffrey Stricsek, Justine Zhang, Renato Iozzo, Robert Rosenwasser, Lorraine Iacovitti
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Neurobiology of Disease
Subjects:
Neural stem cell
Neurogenesis
Recurrent stroke
Blood-brain-barrier
Hippocampus
Dementia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300925

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http://www.sciencedirect.com/science/article/pii/S0969996118300925

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