Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome

Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome

The role of cannabinoid receptors in nephropathy is gaining much attention. This study investigated the effects of two neutral CB1 receptor antagonists, AM6545 and AM4113, on nephropathy associated with metabolic syndrome (MetS). MetS was induced in rats by high-fructose high-salt feeding for 12 wee...

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Bibliografiska uppgifter
Huvudupphovsmän: Basma G. Eid, Thikryat Neamatallah, Abeer Hanafy, Hany M. El-Bassossy, Lenah Binmahfouz, Hibah M. Aldawsari, Atif Hasan, Gamal Abd El-Aziz, Kiran Vemuri, Alexandros Makriyannis
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2021-02-01
Serie:Molecules
Ämnen:
metabolic syndrome
cannabinoids
AM6545
AM4113
kidney
rats
Länkar:https://www.mdpi.com/1420-3049/26/4/866

Internet

https://www.mdpi.com/1420-3049/26/4/866

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