Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response

Tspan8-Tumor Extracellular Vesicle-Induced Endothelial Cell and Fibroblast Remodeling Relies on the Target Cell-Selective Response

Tumor cell-derived extracellular vesicles (TEX) expressing tetraspanin Tspan8-alpha4/beta1 support angiogenesis. Tspan8-alpha6/beta4 facilitates lung premetastatic niche establishment. TEX-promoted target reprogramming is still being disputed, we explored rat endothelial cell (EC) and lung fibroblas...

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Bibliographic Details
Main Authors: Wei Mu, Jan Provaznik, Thilo Hackert, Margot Zöller
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
tumor exosomes
tetraspanin 8
endothelial cells
fibroblasts
message transfer
mrna
ncrna
non-transformed target remodeling
Online Access:https://www.mdpi.com/2073-4409/9/2/319

Internet

https://www.mdpi.com/2073-4409/9/2/319

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