TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking

TGFβ has a role in cancer immunosuppression but the exact mechanisms haven’t been fully elucidated. Here, using mouse models deficient in TGFβ-signaling, the authors show that loss of ALK5 in CD8 + T cells enhances their tumour trafficking and cytotoxicity suggesting that ALK5 inhibitors may have cl...

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Bibliographic Details
Main Authors: Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel Fox, Michaela Phillips, Alejandro Alice, Tiffany Blair, Mark Whiteford, David O’Brien, Rehan Ahmad, Maria X. Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden, Kristina H. Young
Format: Article
Language:English
Published: Nature Portfolio 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15404-8

Internet

https://doi.org/10.1038/s41467-020-15404-8

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