Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice

Null Mutation of the Fascin2 Gene by TALEN Leading to Progressive Hearing Loss and Retinal Degeneration in C57BL/6J Mice

Fascin2 (FSCN2) is an actin cross-linking protein that is mainly localized in retinas and in the stereocilia of hair cells. Earlier studies showed that a deletion mutation in human FASCIN2 (FSCN2) gene could cause autosomal dominant retinitis pigmentosa. Recent studies have indicated that a missense...

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Bibliographic Details
Main Authors: Xiang Liu, Mengmeng Zhao, Yi Xie, Ping Li, Oumei Wang, Bingxin Zhou, Linlin Yang, Yao Nie, Lin Cheng, Xicheng Song, Changzhu Jin, Fengchan Han
Format: Article
Language:English
Published: Oxford University Press 2018-10-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Fascin2
mutation
TALEN
hearing loss
hair cell
retinitis pigmentosa
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200405

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200405

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