Digital Droplet PCR is a Specific and Sensitive Tool for Detecting IDH2 Mutations in Acute Myeloid LeuKemia Patients

Digital Droplet PCR is a Specific and Sensitive Tool for Detecting IDH2 Mutations in Acute Myeloid LeuKemia Patients

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) interfere with cellular metabolism contributing to oncogenesis. Mutations of IDH2 at R140 and R172 residues are observed in 20% of acute myeloid leukemias (AML), and the availability of the IDH2 inhibitor Enasidenib made IDH2 mutational screening a cl...

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Bibliographic Details
Main Authors: Susanna Grassi, Francesca Guerrini, Elena Ciabatti, Riccardo Puccetti, Serena Salehzadeh, Maria Rita Metelli, Alessia Di Vita, Cristiana Domenichini, Francesco Caracciolo, Enrico Orciuolo, Matteo Pelosini, Elisa Mazzantini, Pietro Rossi, Francesco Mazziotta, Mario Petrini, Sara Galimberti
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
digital PCR
IDH2
AML
MRD
CPX-351
Enasidenib
Online Access:https://www.mdpi.com/2072-6694/12/7/1738

Internet

https://www.mdpi.com/2072-6694/12/7/1738

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