The importance of the Thr17 residue of phospholamban as a phosphorylation site under physiological and pathological conditions

The importance of the Thr17 residue of phospholamban as a phosphorylation site under physiological and pathological conditions

The sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) is under the control of an SR protein named phospholamban (PLN). Dephosphorylated PLN inhibits SERCA2a, whereas phosphorylation of PLN at either the Ser16 site by PKA or the Thr17 site by CaMKII reverses this inhibition, thus increasing SERCA2a a...

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Bibliographic Details
Main Authors: A. Mattiazzi, C. Mundiña-Weilenmann, L. Vittone, M. Said, E.G. Kranias
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2006-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Phospholamban
Thr17 site phosphorylation
ß-adrenergic stimulation
Acidosis
Ischemia
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500001

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500001

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