Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder

Context-dependent hyperactivity in syngap1a and syngap1b zebrafish models of SYNGAP1-related disorder

Background and aimsSYNGAP1-related disorder (SYNGAP1-RD) is a prevalent genetic form of Autism Spectrum Disorder and Intellectual Disability (ASD/ID) and is caused by de novo or inherited mutations in one copy of the SYNGAP1 gene. In addition to ASD/ID, SYNGAP1 disorder is associated with comorbid s...

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Bibliographic Details
Main Authors: Sureni H. Sumathipala, Suha Khan, Robert A. Kozol, Yoichi Araki, Sheyum Syed, Richard L. Huganir, Julia E. Dallman
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
zebrafish
sensory-processing
autism
syngap1
haploinsufficiency mutant profiling
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1401746/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2024.1401746/full

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