Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes

Vortioxetine is a novel anti-major depression disorder drug with a high safety profile compared with other similar drugs. However, little research has been done on drug-drug interactions (DDI) about vortioxetine. In this paper, the inhibitory effect of vortioxetine on cytochrome P450 (CYP450) and th...

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Bibliographic Details
Main Authors: Yunyun Zhan, Anzhou Wang, Yige Yu, Jie Chen, Xinhao Xu, Jingjing Nie, Jingjing Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Pharmacology
Subjects:
vortioxetine
inhibition mechanism
drug-drug interaction
CYP450
UPLC-MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1199548/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1199548/full

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