Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant

Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant

Summary: An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu2+” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol, hydroquinone, phloroglucinol, o-phenylenediamine,...

Full description

Bibliographic Details
Main Authors: Wenqian Yu, Shijin Wang, Dongling Cao, Hongyue Rui, Chengcheng Liu, Yongjie Sheng, Yanhong Sun, Jin Zhang, Jiacui Xu, Dazhi Jiang
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Chemistry
Biochemistry
Biocatalysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307471

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220307471

Similar Items